Four 2024 Nobel winners have MIT ties

Acemoglu, an Institute Professor, has been a member of the MIT faculty since 1993. Johnson, the Ronald A. Kurtz Professor of Entrepreneurship at MIT Sloan, was chief economist of the International Monetary Fund from 2007 to 2008.

Meanwhile, Victor Ambros ’75, PhD ’79, a professor at the University of Massachusetts Chan Medical School, and Gary Ruvkun, a professor at Harvard Medical School and Massachusetts General Hospital, shared the prize in medicine for their discovery of microRNA, a class of tiny RNA molecules that help govern gene regulation. This crucial mechanism allows cells with the same chromosomes to develop into cell types with different characteristics and functions.

The foundation for their discoveries was laid by their work on mutant forms of the roundworm C. elegans as MIT postdocs in the lab of Professor H. Robert Horvitz (who would win a Nobel in 2002). Later, working independently, they showed that a certain roundworm gene produces a very short RNA molecule that binds to messenger RNA encoding a different gene and blocks it from being translated into protein. Since then, more than 1,000 microRNA genes have been found in humans.

In an interview with the Journal of Cell Biology, Ambros also credited the contributions of collaborators including his wife, Rosalind “Candy” Lee ’76, and postdoc Rhonda Feinbaum.