“We’re working on trying to create functional replacement teeth,” Pamela Yelick of Tufts University, one of the researchers behind the work, told me. The idea is to develop an alternative to titanium dental implants. Replacing lost or damaged teeth with healthy, living, lab-grown ones might be a more appealing option than drilling a piece of metal into a person’s jawbone.
Current dental implants can work well, but they’re not perfect. They don’t attach to bones and gums in the same way that real teeth do. And around 20% of people who get implants end up developing an infection called peri-implantitis, which can lead to bone loss.
It is all down to the microbes that grow on them. There’s a complex community of microbes living in our mouths, and disruptions can lead to infection. But these organisms don’t just affect our mouths; they also seem to be linked to a growing number of disorders that can affect our bodies and brains. If you’re curious, read on.
The oral microbiome, as it is now called, was first discovered in 1670 by Antonie van Leeuwenhoek, a self-taught Dutch microbiologist. “I didn’t clean my teeth for three days and then took the material that had lodged in small amounts on the gums above my front teeth … I found a few living animalcules,” he wrote in a letter to the Royal Society at the time.
Van Leeuwenhoek had used his own homemade microscopes to study the “animalcules” he found in his mouth. Today, we know that these organisms include bacteria, archaea, fungi, and viruses, each of which comes in lots of types. “Everyone’s mouth is home to hundreds of bacterial species,” says Kathryn Kauffman at the University of Buffalo, who studies the oral microbiome.
These organisms interact with each other and with our own immune systems, and researchers are still getting to grips with how the interactions work. Some microbes feed on sugars or fats in our diets, for example, while others seem to feed on our own cells. Depending on what they consume and produce, microbes can alter the environment of the mouth to either promote or inhibit the growth of other microbes.
This complex microbial dance seems to have a really important role in our health. Oral diseases and even oral cancers have been linked to an imbalance in the oral microbiome, which scientists call “dysbiosis.” Tooth decay, for example, has been attributed to an overgrowth of microbes that produce acids that can damage teeth.
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